Jet Mills

What Is a Jet Mill?

A jet mill is a type of micronizing equipment that uses high-velocity jets of compressed air or gas to grind, reduce, and classify powders. Unlike traditional mechanical milling systems, jet mills contain no moving parts—offering a cleaner, more efficient, and contamination-free grinding solution.

How Does a Jet Mill Work?

Jet mills operate by injecting material into a grinding chamber where high-speed streams of air collide, creating intense turbulence. This air-driven collision pulverizes particles through:

• Inter-particle collisions

• High-speed impacts with chamber walls

• Integrated classifiers that ensure only fine particles exit the chamber

The result? Uniform particle sizes, often in the sub-micron to 10-micron range, with exceptional purity and consistency.

Key Advantages of Jet Milling

• Ultra-Fine Grinding: Ideal for pharmaceutical, chemical, and specialty material industries

• No Heat Generation: Perfect for heat-sensitive or explosive materials

• No Contamination: No mechanical grinding parts means no metal wear or contamination

• Precise Particle Size Control: Built-in air classifiers provide exceptional precision

• Scalable: From R&D to high-volume production

Jet Mill Applications

Our jet mills are used across industries, including:

• Pharmaceuticals – active ingredients, excipients

• Cosmetics – pigments, titanium dioxide

• Food – spices, flavors, nutraceuticals

• Chemicals – polymers, pigments, flame retardants

• Minerals – talc, silica, kaolin

Particle Acceleration: Jet mills utilize compressed gas, typically air, to propel particles at high speeds. This controlled acceleration ensures precise particle size reduction.

Pharmaceutical Industry: Jet mills are indispensable in pharmaceutical manufacturing, producing micron-sized particles crucial for drug formulations. Their ability to handle heat-sensitive materials makes them ideal for pharmaceutical applications.

Precision and Consistency: Jet mills provide unparalleled control over particle size distribution, offering precision and consistency in the final product.

Jet mills have revolutionized particle size reduction by combining efficiency, precision, and versatility. From pharmaceuticals to cosmetics, these high-tech marvels are driving innovation across industries. Embrace the power of jet mills and witness a transformative approach to material processing, ensuring your products meet the highest standards of quality and performance.

How APIs Are Milled Using a Jet Mill by PerMix

PerMix Jet Mills are an advanced solution for milling Active Pharmaceutical Ingredients (APIs), ensuring precision, consistency, and high-quality output. The jet mill process relies on fluid energy milling, where the particles are reduced in size through high-velocity gas streams without the use of mechanical grinding components. Here’s an overview of how APIs are milled using a PerMix Jet Mill:

Process Overview

1. Introduction of Material: APIs are fed into the jet mill’s grinding chamber using a controlled feeder to ensure a consistent supply and prevent clumping.
2. High-Velocity Gas Streams: Compressed gas (commonly air, nitrogen, or steam, depending on the material and application) is introduced at high velocity through specially designed nozzles.
3. Particle Acceleration and Collision:
   • The high-speed gas flow creates turbulence, causing the API particles to accelerate and collide with each other at supersonic speeds.
   • These collisions break the particles down to sub-micron sizes, achieving the desired particle size distribution.
4. Classification:
   • PerMix jet mills feature an integrated dynamic classifier that ensures only particles meeting the target size exit the mill.
   • Oversized particles are returned to the milling chamber for further reduction.
5. Collection of Milled API:
   • The milled APIs are collected in a sterile, contained environment to maintain pharmaceutical-grade cleanliness and prevent contamination.

Advantages of Using PerMix Jet Mills for API Milling

1. Ultra-Fine Particle Size: Jet mills can achieve particle sizes as small as a few microns or even sub-micron levels, making them ideal for APIs requiring precise bioavailability.
2. Temperature Control:
   • The process is inherently low-heat due to the absence of mechanical grinding components, protecting heat-sensitive APIs.
   • Optional cryogenic milling is available for APIs requiring extremely low processing temperatures.
3. No Contamination:
   • The lack of moving parts means there’s no risk of contamination from wear and tear, preserving API purity.
4. Sterile and Contained Process:
   • PerMix Jet Mills are designed for cGMP compliance, ensuring sterile operations essential for pharmaceutical manufacturing.
   • Fully enclosed systems protect the operator and environment from exposure to potent APIs.
5. Scalability:
   • From R&D to full-scale production, PerMix offers jet mills in a variety of sizes to accommodate different batch sizes while maintaining consistent results.
6. Customizable Gas Options:
   • Different gases can be used to suit specific material requirements, such as inert gases for reactive APIs.

Applications in API Milling

PerMix Jet Mills are ideal for:

• Pulmonary drugs requiring ultrafine particles for inhalation.
• Oral solid dosage forms where uniform particle size improves solubility and bioavailability.
• Heat-sensitive APIs that degrade under traditional mechanical milling.

PerMix’s expertise in engineering ensures that our jet mills are tailored to meet the unique challenges of API milling, combining efficiency, precision, and pharmaceutical-grade quality. Contact PerMix for more information on our jet mills and how they can enhance your API manufacturing proces